KMID : 0605720190250030242
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Journal of the Korean Society of Biological Therapies in Psychiatry 2019 Volume.25 No. 3 p.242 ~ p.250
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Comparison of Inflammatory Markers Including C-Reactive Protein between Treatment Resistant Schizophrenia and Non-Treatment Resistant Schizophrenia
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Lee Hyuk-Jun
Chung Myung-Hoon Hong Na-Rei Jon Duk-In
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Abstract
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Objectives£ºThe present study is to investigate inflammatory markers and associated clinical factors between treatment resistant schizophrenia and non-treatment resistant schizophrenia.
Methods£ºOf the 116 schizophrenia subjects who were hospitalized for acute symptomatic treatment, 19 patients (16%) were treated with clozapine as a treatment resistant schizophrenia(TRS) and 97 patients(84%) were treated with other atypical antipsychotics as a non-treatment resistant schizophrenia(Non-TRS). Various inflammatory markers including C-reactive protein(CRP) and clinical factors were retrospectively evaluated with electrical medical records.
Results£ºThere were significant differences between two groups in disease duration( p =0.015), number of admission ( p =0.003), Clinical Global Impression( p £¼0.001) but other demographic and clinical variables including previous antipsychotics use did not show significant differences. In terms of hematologic profiles, TRS group demonstrated higher CRP level( p =0.006), lower neutrophil count( p =0.012), and lower hemoglobin level( p =0.003) compared with non-TRS group. Body mass index was significantly correlated with CRP(r=0.318, p =0.001).
Conclusion£ºThe elevated level of serum CRP in TRS suggests that treatment resistance in schizophrenia may be associated with inflammatory response. However, retrospective study design and small number of subjects could limit this interpretation.
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KEYWORD
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Schizophrenia, C-Reactive Protein, Inflammatory marker, Clozapine
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